Structure of PDB 3aca Chain A

Receptor sequence
>3acaA (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
GKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTADGV
AVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRE
LEEETGYKGDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKP
GDGEFVEVISLPKNDLLQRLDALVAEEHLTVDARVYSYALALKHAN
3D structure
PDB3aca Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.96: ADP-D-ribose pyrophosphorylase.
3.6.1.13: ADP-ribose diphosphatase.
3.6.1.58: 8-oxo-dGDP phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A A96 E116 A84 E104
BS02 MN A E112 E116 E166 E100 E104 E154
BS03 8DD A W28 R51 R84 A96 W16 R39 R72 A84
BS04 8DD A W46 E47 W34 E35
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:3aca, PDBe:3aca, PDBj:3aca
PDBsum3aca
PubMed21768126
UniProtQ9UKK9|NUDT5_HUMAN ADP-sugar pyrophosphatase (Gene Name=NUDT5)

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