Structure of PDB 3aam Chain A

Receptor sequence
>3aamA (length=269) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PRYGFHLSIAGKKGVAGAVEEATALGLTAFQIFAKSPRSWRPRALSPAEV
EAFRALREASGGLPAVIHASYLVNLGAEGELWEKSVASLADDLEKAALLG
VEYVVVHPGSGRPERVKEGALKALRLAGVRSRPVLLVENTAGGGEKVGAR
FEELAWLVADTPLQVCLDTCHAYAAGYDVAEDPLGVLDALDRAVGLERVP
VVHLNDSVGGLGSRVDHHAHLLQGKIGEGLKRVFLDPRLKDRVFILETPR
GPEEDAWNLRVFRAWLEEA
3D structure
PDB3aam An additional C-terminal loop in endonuclease IV, an apurinic/apyrimidinic endonuclease, controls binding affinity to DNA
ChainA
Resolution1.58 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R39 H69 Y72 H108 E139 D169 H172 H204 D217 H219 E248
Catalytic site (residue number reindexed from 1) R38 H68 Y71 H107 E138 D168 H171 H203 D216 H218 E247
Enzyme Commision number 3.1.21.2: deoxyribonuclease IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H172 D217 H219 H171 D216 H218
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 endonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3aam, PDBe:3aam, PDBj:3aam
PDBsum3aam
PubMed21358045
UniProtQ5SK18

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