Structure of PDB 3aaf Chain A

Receptor sequence
>3aafA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
SWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFG
TGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKAN
TESQSLILQ
3D structure
PDB3aaf Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN
ChainA
Resolution1.9 Å
3D
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K976 F977 G978 R993 Y1034 F1037 M1038 K1039 K21 F22 G23 R38 Y79 F82 M83 K84 PDBbind-CN: Kd=253nM
BS02 dna A R987 S989 N990 S991 Q992 K1036 F1037 R32 S34 N35 S36 Q37 K81 F82 PDBbind-CN: Kd=253nM
Gene Ontology
Molecular Function
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3aaf, PDBe:3aaf, PDBj:3aaf
PDBsum3aaf
PubMed20159463
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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