Structure of PDB 3a7n Chain A

Receptor sequence
>3a7nA (length=233) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
HHGMASMTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLP
AGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSL
ANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKG
WEAVTECAIRALAARAAPLVAILWGRDASTLKPMLAAGNCVAIESPHPSP
LSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
3D structure
PDB3a7n Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D68 Y70 F81 H191
Catalytic site (residue number reindexed from 1) D74 Y76 F87 H197
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A Q67 D68 Y70 S80 F81 S93 N127 H191 Q73 D74 Y76 S86 F87 S99 N133 H197
BS02 FLC A H-5 G-3 M-2 Y42 A45 G46 H1 G3 M4 Y48 A51 G52
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0097510 base-excision repair, AP site formation via deaminated base removal
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3a7n, PDBe:3a7n, PDBj:3a7n
PDBsum3a7n
PubMed20693660
UniProtP9WFQ9|UNG_MYCTU Uracil-DNA glycosylase (Gene Name=ung)

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