Structure of PDB 3a7i Chain A

Receptor sequence
>3a7iA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
MQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED
EIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE
PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLAD
FGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIEL
ARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFR
PTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQS
3D structure
PDB3a7i Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
ChainA
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 D171 T182
Catalytic site (residue number reindexed from 1) D132 K134 A136 N137 D150 D159 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A A51 E100 Y101 L102 L151 A39 E88 Y89 L90 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3a7i, PDBe:3a7i, PDBj:3a7i
PDBsum3a7i
PubMed20124694
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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