Structure of PDB 3a79 Chain A

Receptor sequence
>3a79A (length=550) Species: 7764,10090 [Search protein sequence]
ESLSCDASGVCDGRSRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRAC
ANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSS
LKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTS
LNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVR
YLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRY
ILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLF
YDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEE
YLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTF
HPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLF
LPRLQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFDRLTSL
QKIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGKPVRSIICP
3D structure
PDB3a79 Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D294 F325 Y326 D327 L350 P352 D269 F300 Y301 D302 L325 P327
BS02 PXS A L261 F266 L269 F284 L317 F325 S346 K347 V348 F349 L350 P352 F355 L236 F241 L244 F259 L292 F300 S321 K322 V323 F324 L325 P327 F330
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3a79, PDBe:3a79, PDBj:3a79
PDBsum3a79
PubMed19931471
UniProtQ4G1L2;
Q9QUN7|TLR2_MOUSE Toll-like receptor 2 (Gene Name=Tlr2)

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