Structure of PDB 3a6t Chain A

Receptor sequence
>3a6tA (length=127) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAVVR
ELQEEVGITPQHFSLFEKLEYEFPDRHITLWFWLVERWEGEPWGKEGQPG
EWMSLVGLNADDFPPANEPVIAKLKRL
3D structure
PDB3a6t Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.55: 8-oxo-dGTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A E47 H64 F65 E45 H62 F63
BS02 8OG A I6 V8 R23 H28 E34 F35 G37 I80 L82 P116 N119 I4 V6 R21 H26 E32 F33 G35 I78 L80 P114 N117 MOAD: Kd=52nM
PDBbind-CN: -logKd/Ki=7.28,Kd=52nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0044715 8-oxo-dGDP phosphatase activity
GO:0044716 8-oxo-GDP phosphatase activity
GO:0046872 metal ion binding
GO:0047693 ATP diphosphatase activity
Biological Process
GO:0006203 dGTP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0046067 dGDP catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3a6t, PDBe:3a6t, PDBj:3a6t
PDBsum3a6t
PubMed19864691
UniProtP08337|MUTT_ECOLI 8-oxo-dGTP diphosphatase (Gene Name=mutT)

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