Structure of PDB 3a62 Chain A

Receptor sequence
>3a62A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAERNILE
EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY
LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCHTFCGTIE
YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC
KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWE
ELLARKVEPPFKPL
3D structure
PDB3a62 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D120 K122 E124 N125 D138 T148
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L97 V105 A121 E173 Y174 L175 E179 E222 M225 T235 D236 L13 V21 A37 E75 Y76 L77 E81 E124 M127 T137 D138
BS02 MN A C240 H251 C254 C142 H143 C146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3a62, PDBe:3a62, PDBj:3a62
PDBsum3a62
PubMed19864428
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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