Structure of PDB 3a61 Chain A

Receptor sequence
>3a61A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKAERNILEEVK
HPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE
ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGGTIEYMAPEILMR
SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLT
QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEP
PFKP
3D structure
PDB3a61 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
ChainA
Resolution3.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D117 K119 E121 N122 D135 T139
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L97 A121 Y174 L175 E179 N223 M225 T235 D236 L11 A35 Y73 L74 E78 N122 M124 T134 D135
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3a61, PDBe:3a61, PDBj:3a61
PDBsum3a61
PubMed19864428
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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