Structure of PDB 3a4v Chain A

Receptor sequence
>3a4vA (length=311) Species: 50339 (Thermoplasma volcanium) [Search protein sequence]
MILVTGSSGQIGTELVPYLAEKYGKKNVIASDIVQRDTGGIKFITLDVSN
RDEIDRAVEKYSIDAIFHLAGILSAKGEKDPALAYKVNMNGTYNILEAAK
QHRVEKVVIPSTIGVFGPETPKNKVPSITITRPRTMYGVTKIAAELLGQY
YYEKFGLDVRSLRYPGIISYKAEPTAGTTDYAVEIFYYAVKREKYKCYLA
PNRALPMMYMPDALKALVDLYEADRDKLVLRNGYNVTAYTFTPSELYSKI
KERIPEFEIEYKEDFRDKIAATWPESLDSSEASNEWGFSIEYDLDRTIDD
MIDHISEKLGI
3D structure
PDB3a4v Crystal Structure of Binary and Ternary Complexes of Archaeal UDP-galactose 4-Epimerase-like L-Threonine Dehydrogenase from Thermoplasma volcanium.
ChainA
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T112 Y137 K141
Catalytic site (residue number reindexed from 1) T112 Y137 K141
Enzyme Commision number 1.1.1.103: L-threonine 3-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A S8 G9 Q10 I11 D32 I33 L46 D47 V48 L69 A70 G71 L73 P110 S111 T112 Y137 K141 Y164 I167 S8 G9 Q10 I11 D32 I33 L46 D47 V48 L69 A70 G71 L73 P110 S111 T112 Y137 K141 Y164 I167
BS02 PYR A S74 Y137 T178 T179 W273 S74 Y137 T178 T179 W273 MOAD: Ki=23.2mM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008743 L-threonine 3-dehydrogenase activity
Biological Process
GO:0006567 threonine catabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3a4v, PDBe:3a4v, PDBj:3a4v
PDBsum3a4v
PubMed22374996
UniProtQ97BK3

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