Structure of PDB 3a2c Chain A

Receptor sequence
>3a2cA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ
DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGEL
FSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS
KRPNAILKLTDFGFAKETTSVAPEVLYDKSCDMWSLGVIMYILLCGYPPF
YSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM
NHPWIMQSTKVPQTPLHTSRVLKE
3D structure
PDB3a2c Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 S216
Catalytic site (residue number reindexed from 1) D140 K142 E144 N145 D161 S170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PDY A V78 Q80 C140 L141 E190 N191 L193 D207 V32 Q34 C94 L95 E144 N145 L147 D161 PDBbind-CN: -logKd/Ki=6.90,Ki=0.126uM
BindingDB: IC50=130nM
BS02 PDY A Y260 P261 Y264 Y197 P198 Y201 PDBbind-CN: -logKd/Ki=6.90,Ki=0.126uM
BindingDB: IC50=130nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3a2c, PDBe:3a2c, PDBj:3a2c
PDBsum3a2c
PubMed20057052
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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