Structure of PDB 3a27 Chain A

Receptor sequence
>3a27A (length=219) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
KYQKIGDVVIVCKAILLYTHVKILYGKETETIHKEYGCLFKLDVAKIMWS
QGNIEERKRMAFISNENEVVVDMFAGIGYFTIPLAKYSKPKLVYAIEKNP
TAYHYLCENIKLNKLNNVIPILADNRDVELKDVADRVIMGYVHKTHKFLD
KTFEFLKDRGVIHYHETVAEKIMYERPIERLKFYAEKNGYKLIDYEVRKI
KKYAPGVWHVVVDAKFERI
3D structure
PDB3a27 Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
ChainA
Resolution2.005 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.114: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A S80 N83 F104 Y109 E127 K128 D154 N155 Y171 S50 N53 F74 Y79 E97 K98 D124 N125 Y141
Gene Ontology
Molecular Function
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:3a27, PDBe:3a27, PDBj:3a27
PDBsum3a27
PubMed19717466
UniProtQ58952|TYW2_METJA tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase (Gene Name=taw2)

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