Structure of PDB 3a26 Chain A

Receptor sequence
>3a26A (length=264) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
IKPRIREILSKELPEELVKLLPKRWVRIGDVLLLPLRPELEPYKHRIAEV
YAEVLGVKTVLRKGDYELLYGSDTVTVHVENGIKYKLDVAKIMFSPANVK
ERVRMAKVAKPDELVVDMFAGIGHLSLPIAVYGKAKVIAIEKDPYTFKFL
VENIHLNKVEDRMSAYNMDNRDFPGENIADRILMGYVVRTHEFIPKALSI
AKDGAIIHYHNTVPEKLMPREPFETFKRITKEYGYDVEKLNELKIKRYAP
GVWHVVLDLRVFKS
3D structure
PDB3a26 Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.114: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A M132 F133 G135 E155 K156 D183 N184 M118 F119 G121 E141 K142 D169 N170
Gene Ontology
Molecular Function
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0031591 wybutosine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3a26, PDBe:3a26, PDBj:3a26
PDBsum3a26
PubMed19717466
UniProtO58523|TYW2_PYRHO tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase (Gene Name=taw2)

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