Structure of PDB 3a06 Chain A

Receptor sequence
>3a06A (length=370) Species: 2336 (Thermotoga maritima) [Search protein sequence]
ERTLVILGATGSIGTQTLDVLKKVKGIRLIGISFHSNLELAFKIVKEFNV
KNVAITGDVEFEDSSINVWKGSHSIEEMLEALKPDITMVAVSGFSGLRAV
LASLEHSKRVCLANKESLVCGGFLVKKKLKEKGTELIPVDSEHSAIFQVM
EPEVEKVVLTASGGALRDWKISKIDRARPEDVLKHPVWNMGARITVDSAT
MVNKAFEVLEAMELFELPFEKIEVKIHREGLVHGAVVLPDGNVKMVVSPP
DMRIPISYALFYPRRVALEPFFLRTISLSFEDPDPEKYPAFFLLKEIKDS
YALRTAFNAADEVAVEAFLKGRIRFGGIHRVIEKTLEEFQGYPQPRTLDD
VERIHFEAIKKAERVTEWLS
3D structure
PDB3a06 Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G10 T12 G13 S14 I15 H37 S38 N39 T58 A92 V93 S94 S97 A115 N116 K117 I196 M254 G8 T10 G11 S12 I13 H35 S36 N37 T56 A90 V91 S92 S95 A113 N114 K115 I194 M252
BS02 NDP A R30 L31 F50 R28 L29 F48
BS03 FOM A S164 W190 K206 S162 W188 K204 MOAD: ic50~100nM
BS04 MG A D142 E209 D140 E207
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3a06, PDBe:3a06, PDBj:3a06
PDBsum3a06
PubMed20353826
UniProtQ9WZZ1|DXR_THEMA 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

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