Structure of PDB 2zzb Chain A

Receptor sequence

>2zzbA (length=490) Species: 9606 (Homo sapiens)

SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTC
VNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHI
GSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLI
ATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFL
AGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQI
EAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKI
NEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYA
GSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPL
EWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCG
LTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG

3D structure

• PDB: 2zzb Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1.
• Chain: A
• Resolution: 3.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L55 C59 C64 K67 Y200 E204 G470 H472 E477 G496 C497
• Catalytic site (residue number reindexed from 1): L46 C50 C55 K58 Y191 E195 G461 H463 E468 G487 C488
• Enzyme Commision number: 1.11.1.2: NADPH peroxidase.
  1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I18 G19 G21 S22 D42 F43 V44 T58 C59 V62 G63 C64 K67 Y131 G132 T161 Y200 V201 R293 G333 D334 E341 L342 T343	I9 G10 G12 S13 D33 F34 V35 T49 C50 V53 G54 C55 K58 Y122 G123 T152 Y191 V192 R284 G324 D325 E332 L333 T334

Gene Ontology

Molecular Function

• GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
• GO:0016491 oxidoreductase activity
• GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0045454 cell redox homeostasis

External links

• PDB: RCSB:2zzb, PDBe:2zzb, PDBj:2zzb
• PDBsum: 2zzb
• PubMed: 19525010
• UniProt: Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic (Gene Name=TXNRD1)