Structure of PDB 2zz5 Chain A

Receptor sequence
>2zz5A (length=213) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence]
MDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAE
FRKRFGCRIIAAFAVADIPETNEKICRATFKAGADAIIVHGFPGADSVRA
CLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPS
TRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLA
DNPAAAAAGIIES
3D structure
PDB2zz5 Structural characterization of the molecular events during a slow substrate-product transition in orotidine 5'-monophosphate decarboxylase
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6CN A D20 K42 M126 S127 P180 Q185 G202 R203 D12 K34 M118 S119 P172 Q177 G194 R195 BindingDB: Ki=29000nM
BS02 6CN A D75 I76 T79 D67 I68 T71 BindingDB: Ki=29000nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:2zz5, PDBe:2zz5, PDBj:2zz5
PDBsum2zz5
PubMed19236876
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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