Structure of PDB 2zyq Chain A

Receptor sequence
>2zyqA (length=296) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARL
VVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRV
DEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTR
DDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHS
LAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPMSATLGRHVNDL
MLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVG
3D structure
PDB2zyq Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.25: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5- dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H145 H215 E266 H144 H214 E265
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0046872 metal ion binding
GO:0047071 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0016042 lipid catabolic process
GO:0070723 response to cholesterol

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Molecular Function
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Biological Process
External links
PDB RCSB:2zyq, PDBe:2zyq, PDBj:2zyq
PDBsum2zyq
PubMed19300498
UniProtP9WNW7|HSAC_MYCTU Iron-dependent extradiol dioxygenase (Gene Name=hsaC)

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