Structure of PDB 2zu3 Chain A

Receptor sequence
>2zu3A (length=180) Species: 12072 (Coxsackievirus B3) [Search protein sequence]
GPAFEFAVAMMKRNSSTVKTEYGEFTMLGIYDRWAVLPRHAKPGPTILMN
DQEVGVLDAKELVDKDGTNLELTLLKLNRNEKFRDIRGFLAKEEVEVNEA
VLAINTSKFPNMYIPVGQVTEYGFLNLGGTPTKRMLMYNFPTRAGQCGGV
LMSTGKVLGIHVGGNGHQGFSAALLKHYFN
3D structure
PDB2zu3 Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H40 E71 G145 C147
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZU3 A H40 E71 L127 G128 T142 A144 G145 C147 H161 V162 G163 G164 N165 H40 E71 L127 G128 T142 A144 G145 C147 H161 V162 G163 G164 N165 PDBbind-CN: -logKd/Ki=6.10,Ki=0.8uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2zu3, PDBe:2zu3, PDBj:2zu3
PDBsum2zu3
PubMed19144641
UniProtP03313|POLG_CXB3N Genome polyprotein

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