Structure of PDB 2ztm Chain A

Receptor sequence
>2ztmA (length=255) Species: 296 (Pseudomonas fragi) [Search protein sequence]
VAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLAAQHGV
KVLYDGADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIEDFPTE
KWDAILALNLSAVFHGTAAALPHMKKQGFGRIINIASAHGLVASANKSAY
VAAKHGVVGFTKVTALETAGQGITANAICPGWVRSPLVEKQISALAEKNG
VDQETAARELLSEKQPSLQFVTPEQLGGTAVFLASDAAAQITGTTVSVDG
GWTAR
3D structure
PDB2ztm Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15 N114 S142 Y155 K159 L200
Catalytic site (residue number reindexed from 1) G10 N109 S137 Y150 K154 L195
Enzyme Commision number 1.1.1.30: 3-hydroxybutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G11 S14 G15 I16 G35 F36 L64 N90 G92 L113 S142 Y155 K159 P185 V188 S190 V193 G6 S9 G10 I11 G30 F31 L59 N85 G87 L108 S137 Y150 K154 P180 V183 S185 V188
BS02 3HL A Q94 S142 H144 K152 Y155 Q196 W257 Q89 S137 H139 K147 Y150 Q191 W252
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2ztm, PDBe:2ztm, PDBj:2ztm
PDBsum2ztm
PubMed19122202
UniProtQ5KST5

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