Structure of PDB 2zr2 Chain A

Receptor sequence
>2zr2A (length=447) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MLDIKLIRENPELVKNDLIKRGELEKVKWVDEILKLDTEWRTKLKEINRL
RHERNKIAVEIGKRRKKGEPVDELLAKSREIVKRIGELENEVEELKKKID
YYLWRLPNITHPSVPVGKDENDNVPIRFWGKARVWKGHLERFLEQSQGKM
EYEILEWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALI
RFALDRLIEKGFTPVIPPYMVRRFVEEGSTSFEDFEDVIYKVEDEDLYLI
PTAEHPLAGMHANEILDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVH
QFHKVEQFVYSRPEESWEWHEKIIRNAEELFQELEIPYRVVNICTGDLGY
VAAKKYDIEAWMPGQGKFREVVSASNCTDWQARRLNIRFRDRTDEKPRYV
HTLNSTAIATSRAIVAILENHQEEDGTVRIPKVLWKYTGFKEIVPVE
3D structure
PDB2zr2 Crystallographic and mutational studies of seryl-tRNA synthetase from the archaeon Pyrococcus horikoshii.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R283 R298 E370 S373 R412
Catalytic site (residue number reindexed from 1) R283 R298 E370 S373 R412
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A R283 E285 F297 R298 V299 F302 E370 V371 V372 T406 A409 S411 R412 R283 E285 F297 R298 V299 F302 E370 V371 V372 T406 A409 S411 R412
BS02 SO4 A S183 R184 A289 H300 S183 R184 A289 H300
BS03 SO4 A K291 D292 T293 R298 K291 D292 T293 R298
BS04 SO4 A R298 R369 E370 R298 R369 E370
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2zr2, PDBe:2zr2, PDBj:2zr2
PDBsum2zr2
PubMed18818520
UniProtO58441|SYS_PYRHO Serine--tRNA ligase (Gene Name=serS)

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