Structure of PDB 2zpu Chain A

Receptor sequence
>2zpuA (length=319) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
LVLPTYDDVASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMG
AFKFRGALNALSQLNEAQRKAGVLTFSSGNHAQAIALSAKILGIPAKIIM
PLDAPEAKVAATKGYGGQVIMYDRYKDDREKMAKEISEREGLTIIPPYDH
PHVLAGQGTAAKELFEEVGPLDALFVCLGGGGLLSGSALAARHFAPNCEV
YGVEPEAGNDGQQSFRKGSIVHIDTPKTIADGAQTQHLGNYTFSIIKEKV
DDILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAARAMKEKLKNKRIG
IIISGGNVDIERYAHFLSQ
3D structure
PDB2zpu Serine racemase with catalytically active lysinoalanyl residue.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K57 S82 E208 G212 D214 G236 I307 S308
Catalytic site (residue number reindexed from 1) K53 S78 E204 G208 D210 G232 I303 S304
Enzyme Commision number 4.3.1.17: L-serine ammonia-lyase.
4.3.1.18: D-serine ammonia-lyase.
5.1.1.18: serine racemase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E208 G212 D214 E204 G208 D210
BS02 PDD A F56 K57 S81 S82 N84 H85 P151 G183 G184 G185 G186 G236 E281 T283 S308 F52 K53 S77 S78 N80 H81 P147 G179 G180 G181 G182 G232 E277 T279 S304
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003941 L-serine ammonia-lyase activity
GO:0005524 ATP binding
GO:0008721 D-serine ammonia-lyase activity
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018114 threonine racemase activity
GO:0030170 pyridoxal phosphate binding
GO:0030378 serine racemase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0070178 D-serine metabolic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zpu, PDBe:2zpu, PDBj:2zpu
PDBsum2zpu
PubMed19155267
UniProtO59791|SRR_SCHPO Serine racemase (Gene Name=sry1)

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