Structure of PDB 2zpa Chain A

Receptor sequence
>2zpaA (length=658) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AELTALHTLTAQMKREGIRRLLVLSGEEGWCFEHTLKLRDALPGDWLWIS
PRPQTLLGREFRHAVFDARHGFDAAAFAALSGTLKAGSWLVLLLPVWEEW
ENQPDADSLRWSDCPDPIATPHFVQHLKRVLTADNEAILWRQNQPFSLAH
FTPRTDWYPATGAPQPEQQQLLKQLMTMPPGVAAVTAARGRGKSALAGQL
ISRIAGRAIVTAPAKASTDVLAQFAGEKFRFIAPDALLASDEQADWLVVD
EAAAIPAPLLHQLVSRFPRTLLTTTVQGYEGTGRGFLLKFCARFPHLHRF
ELQQPIRWAQGCPLEKMVSEALVFDDENFTHTPQGNIVISAFEQTLWQSD
PETPLKVYQLLSGAHYRTSPLDLRRMMDAPGQHFLQAAGENEIAGALWLV
DEGGLSQQLSQAVWAGFRRPRGNLVAQSLAAHGNNPLAATLRGRRVSRIA
VHPARQREGTGRQLIAGALQYTQDLDYLSVSFGYTGELWRFWQRCGFVLV
RMGNHREASSGCYTAMALLPMSDAGKQLAEREHYRLRRDAQALAQWNGET
LPVDPLNDAVLSDDDWLELAGFAFAHRPLLTSLGCLLRLLQTSELALPAL
RGRLQKNASDAQLCTTLKLSGRKMLLVRQREEAAQALFALNDVRTERLRD
RITQWQLF
3D structure
PDB2zpa RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.193: tRNA(Met) cytidine acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A I461 V463 Q468 R469 G471 G473 R474 E499 L500 F503 R506 I449 V451 Q456 R457 G459 G461 R462 E487 L488 F491 R494
BS02 ADP A A172 G174 A175 Q180 G202 R203 G204 K205 S206 A207 V232 F236 I318 R319 A160 G162 A163 Q168 G190 R191 G192 K193 S194 A195 V220 F224 I306 R307
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0051392 tRNA N-acetyltransferase activity
GO:0106226 peptide 2-hydroxyisobutyryltransferase activity
Biological Process
GO:0002101 tRNA wobble cytosine modification
GO:0008033 tRNA processing
GO:0051391 tRNA acetylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zpa, PDBe:2zpa, PDBj:2zpa
PDBsum2zpa
PubMed19322199
UniProtP76562|TMCA_ECOLI tRNA(Met) cytidine acetyltransferase TmcA (Gene Name=tmcA)

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