Structure of PDB 2zog Chain A

Receptor sequence

>2zogA (length=478) Species: 10090 (Mus musculus)

SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMME
VAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCI
YGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEA
YQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDN
YWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISL
MGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETL
LHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVP
DMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQA
GRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHS
QNEKLNRLNYIEGTKMLAAYLYEVSQLK

3D structure

• PDB: 2zog Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Enzyme Commision number: 3.4.13.18: cytosol non-specific dipeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D132 E167 H445	D136 E171 H449
BS02	ZN	A	H99 D132 D195	H103 D136 D199
BS03	BES	A	H99 D132 E166 E167 D195 Y197 R343 E414 S417 H445	H103 D136 E170 E171 D199 Y201 R347 E418 S421 H449
BS04	BES	A	H228 T330	H232 T334

Gene Ontology

Molecular Function

• GO:0004180 carboxypeptidase activity
• GO:0008233 peptidase activity
• GO:0008237 metallopeptidase activity
• GO:0016787 hydrolase activity
• GO:0016805 dipeptidase activity
• GO:0046872 metal ion binding
• GO:0070573 metallodipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2zog, PDBe:2zog, PDBj:2zog
• PDBsum: 2zog
• PubMed: 18550540
• UniProt: Q9D1A2|CNDP2_MOUSE Cytosolic non-specific dipeptidase (Gene Name=Cndp2)