Structure of PDB 2znr Chain A

Receptor sequence
>2znrA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
GPGHMEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTI
THVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSS
VDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFH
PHTKEPRLFSICKHVLVKDIKIIVLDLR
3D structure
PDB2znr Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H362 C402 H408 H410 H104 C144 H150 H152
BS02 ZN A H347 H349 D360 H89 H91 D102
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0070536 protein K63-linked deubiquitination

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2znr, PDBe:2znr, PDBj:2znr
PDBsum2znr
PubMed18758443
UniProtQ96FJ0|STALP_HUMAN AMSH-like protease (Gene Name=STAMBPL1)

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