Structure of PDB 2znp Chain A

Receptor sequence
>2znpA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
LKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEK
GLVLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTL
LKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPK
FEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRAL
EFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHP
LLQEIYKDM
3D structure
PDB2znp Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7G A V293 K319 E471 V76 K102 E254
BS02 K55 A R284 C285 T288 T289 H323 L330 L339 V341 V348 H449 M453 R67 C68 T71 T72 H106 L113 L122 V124 V131 H232 M236 BindingDB: EC50=0.72nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2znp, PDBe:2znp, PDBj:2znp
PDBsum2znp
PubMed19622862
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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