Structure of PDB 2zmi Chain A

Receptor sequence
>2zmiA (length=242) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLAD
LVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMD
DMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVL
LMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAK
MIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB2zmi Crystal structures of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and partial agonism
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 I256 K260 P412 E416 I60 K64 S74 I78 K82 P234 E238
BS02 TT2 A Y143 F150 L223 A227 S233 M268 R270 S271 S274 W282 C284 A299 H301 H393 L410 Y23 F30 L45 A49 S55 M90 R92 S93 S96 W104 C106 A121 H123 H215 L232 MOAD: ic50=3nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2zmi, PDBe:2zmi, PDBj:2zmi
PDBsum2zmi
PubMed18710208
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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