Structure of PDB 2zmf Chain A

Receptor sequence
>2zmfA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
QTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK
NKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPD
AYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSK
TDENNFKMFAVFCALALHCANMYHRIR
3D structure
PDB2zmf Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A R286 F304 D305 F324 G329 I330 A331 F352 N353 V356 T364 Q383 R41 F59 D60 F79 G84 I85 A86 F107 N108 V111 T119 Q138
External links
PDB RCSB:2zmf, PDBe:2zmf, PDBj:2zmf
PDBsum2zmf
PubMed18477562
UniProtQ9Y233|PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=PDE10A)

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