Structure of PDB 2zmd Chain A

Receptor sequence
>2zmdA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTL
DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKK
KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDF
GIANQMDSQVGAVNYMPPEAIKDMISPKSDVWSLGCILYYMTYGKTPFQQ
IINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELL
AHPYVQIQT
3D structure
PDB2zmd Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
ChainA
Resolution2.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N556 L565 D647 K649 N652 D664 A686
Catalytic site (residue number reindexed from 1) N41 L50 D132 K134 N137 D149 A162
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 537 A I531 A551 I586 M602 E603 G605 L654 I16 A36 I71 M87 E88 G90 L139 PDBbind-CN: -logKd/Ki=7.01,Kd=0.098uM
BindingDB: IC50=98nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2zmd, PDBe:2zmd, PDBj:2zmd
PDBsum2zmd
PubMed18480048
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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