Structure of PDB 2zke Chain A

Receptor sequence

>2zkeA (length=210) Species: 10090 (Mus musculus) [Search protein sequence]

SGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAG
IHGRSNDGAYSLVLAGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSD
QKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAP
AEGNRYDGIYKVVKYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTR
QLGLTMQYPE

3D structure

PDB

2zke Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	A407 C408 G410 R411 H450 H455 G456 R457 S458 N494 R496 N508	A4 C5 G7 R8 H47 H52 G53 R54 S55 N91 R93 N105
BS02	dna	A	S404 G405 M406 A407 F437 R438 V451 A452 G453 A468 Y471 D474 Y483 T484 S486 G487 R496	S1 G2 M3 A4 F34 R35 V48 A49 G50 A65 Y68 D71 Y80 T81 S83 G84 R93

External links

PDB	RCSB:2zke, PDBe:2zke, PDBj:2zke
PDBsum	2zke
PubMed	18772891
UniProt	Q8VDF2\|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Gene Name=Uhrf1)

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