Structure of PDB 2zjo Chain A

Receptor sequence
>2zjoA (length=444) Species: 31645 (Hepatitis C virus (isolate Taiwan)) [Search protein sequence]
NSSPPAVPQAFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATL
GFGAYMSKAHGVDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDI
IMCDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNI
EEIALSNTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSALGI
HAVAYYRGLDVSVIPASGNVVVVATDALMTGFTGDFDSVIDCNTCVTQTV
DFSLDPTFTIETTTMPQDAVSRSQRRGRTSRGRRGIYRFVTPGERPSGMF
DSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVF
TGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLT
RLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVV
3D structure
PDB2zjo Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BHT A G207 G209 S211 T212 S231 A233 F238 G21 G23 S25 T26 S45 A47 F52
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2zjo, PDBe:2zjo, PDBj:2zjo
PDBsum2zjo
PubMed
UniProtP29846|POLG_HCVTW Genome polyprotein

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