Structure of PDB 2zi7 Chain A

Receptor sequence
>2zi7A (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVQSTGGNVLQ
MMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSD
RYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPE
TCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLVPILTLDVNEDF
KDKYESLVEKVKEFLSTL
3D structure
PDB2zi7 Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
ChainA
Resolution1.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E53 R128
Catalytic site (residue number reindexed from 1) E33 R95
Enzyme Commision number 2.7.1.113: deoxyguanosine kinase.
2.7.1.74: deoxycytidine kinase.
2.7.1.76: deoxyadenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNG A I30 E53 W58 Y86 F96 Q97 R104 R128 F137 E197 I10 E33 W38 Y53 F63 Q64 R71 R95 F104 E164
BS02 UDP A A31 G33 K34 S35 T36 R188 L191 R192 D241 F242 K243 A11 G13 K14 S15 T16 R155 L158 R159 D199 F200 K201
Gene Ontology
Molecular Function
GO:0004136 deoxyadenosine kinase activity
GO:0004137 deoxycytidine kinase activity
GO:0004138 deoxyguanosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019136 deoxynucleoside kinase activity
GO:0042803 protein homodimerization activity
GO:0043771 cytidine kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0106383 dAMP salvage
GO:1901135 carbohydrate derivative metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zi7, PDBe:2zi7, PDBj:2zi7
PDBsum2zi7
PubMed18570408
UniProtP27707|DCK_HUMAN Deoxycytidine kinase (Gene Name=DCK)

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