Structure of PDB 2zi6 Chain A

Receptor sequence

>2zi6A (length=217) Species: 9606 (Homo sapiens)

RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWGGNVLQMMYEK
PERWSFTFQTYACLSRIRAQLASLNAEKPVLFFERSVYSDRYIFASNLYE
SESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRG
RNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFK
DKYESLVEKVKEFLSTL

3D structure

• PDB: 2zi6 Structural basis for substrate promiscuity of dCK
• Chain: A
• Resolution: 1.77 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.113: deoxyguanosine kinase.
  2.7.1.74: deoxycytidine kinase.
  2.7.1.76: deoxyadenosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDP	A	A1031 G1033 K1034 S1035 T1036 R1188 R1192 D1241 F1242 K1243	A12 G14 K15 S16 T17 R145 R149 D198 F199 K200
BS02	3D1	A	E1053 V1055 Y1086 F1096 Q1097 D1133 F1137	E34 V36 Y48 F58 Q59 D90 F94

Gene Ontology

Molecular Function

• GO:0004136 deoxyadenosine kinase activity
• GO:0004137 deoxycytidine kinase activity
• GO:0004138 deoxyguanosine kinase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0019136 deoxynucleoside kinase activity
• GO:0042803 protein homodimerization activity
• GO:0043771 cytidine kinase activity

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006220 pyrimidine nucleotide metabolic process
• GO:0009224 CMP biosynthetic process
• GO:0016310 phosphorylation
• GO:0106383 dAMP salvage
• GO:1901135 carbohydrate derivative metabolic process
• GO:1901293 nucleoside phosphate biosynthetic process

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005829 cytosol

External links

• PDB: RCSB:2zi6, PDBe:2zi6, PDBj:2zi6
• PDBsum: 2zi6
• PubMed: 18377927
• UniProt: P27707|DCK_HUMAN Deoxycytidine kinase (Gene Name=DCK)