Structure of PDB 2zfn Chain A

Receptor sequence
>2zfnA (length=376) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MAAMMSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKST
IKTQHFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNT
RVSVRDITKIILEFILSIDPNYYLQKVKPAIRSYKKISPELISAASLYLS
FTCPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDR
LLIECFQNDTQAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLA
VYNIPLFPDDPKARFIHQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSS
VMGISGYSLATPSLFPSSADVIVPKSRKQFRAIKKYITGEEYDTEEGAIE
AFTNIRDFLLLRMATNLQSLTGKREH
3D structure
PDB2zfn Structural insights into histone h3 lysine 56 acetylation by rtt109
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A K87 A88 D89 T90 V100 R101 F192 R194 A196 Y199 K210 H211 L213 L218 W221 W222 K91 A92 D93 T94 V104 R105 F164 R166 A168 Y171 K182 H183 L185 L190 W193 W194
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0010484 histone H3 acetyltransferase activity
GO:0016740 transferase activity
GO:0032931 histone H3K56 acetyltransferase activity
GO:0036408 histone H3K14 acetyltransferase activity
GO:0043992 histone H3K9 acetyltransferase activity
GO:0043994 histone H3K23 acetyltransferase activity
GO:0044017 histone H3K27 acetyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 DNA damage response
GO:0010468 regulation of gene expression
GO:0010526 retrotransposon silencing
GO:0033554 cellular response to stress
GO:0036211 protein modification process
GO:0043007 maintenance of rDNA
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0070775 H3 histone acetyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zfn, PDBe:2zfn, PDBj:2zfn
PDBsum2zfn
PubMed18707894
UniProtQ07794|RT109_YEAST Histone acetyltransferase RTT109 (Gene Name=RTT109)

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