Structure of PDB 2zeu Chain A

Receptor sequence

>2zeuA (length=305) Species: 4932 (Saccharomyces cerevisiae)

NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKNFRLNLIVQINRVMN
LPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTIN
TANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDF
LPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGII
YQIRDDYLNLKDFQMGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEIL
RILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNELLYIID
HLSEL

3D structure

• PDB: 2zeu Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.5.1.-
  2.5.1.1: dimethylallyltranstransferase.
  2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
  2.5.1.29: geranylgeranyl diphosphate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	B71	A	L47 D80 R89 K174 F179 T182 Q211 D214 K238	L41 D74 R83 K168 F173 T176 Q202 D205 K225

Gene Ontology

Molecular Function

• GO:0004161 dimethylallyltranstransferase activity
• GO:0004311 farnesyltranstransferase activity
• GO:0004337 geranyltranstransferase activity
• GO:0004659 prenyltransferase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008299 isoprenoid biosynthetic process
• GO:0015031 protein transport
• GO:0016114 terpenoid biosynthetic process
• GO:0033384 geranyl diphosphate biosynthetic process
• GO:0033386 geranylgeranyl diphosphate biosynthetic process
• GO:0045337 farnesyl diphosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:2zeu, PDBe:2zeu, PDBj:2zeu
• PDBsum: 2zeu
• PubMed: 19309137
• UniProt: Q12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)