Structure of PDB 2zej Chain A

Receptor sequence
>2zejA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
MKLMIVGNTGSGKTTLLQQLMKTVGIDVKDWPILVLNVWDFAGREEFYST
HPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHL
DVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTI
INESLNF
3D structure
PDB2zej Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G1344 G1346 K1347 T1348 T1349 G10 G12 K13 T14 T15
BS02 GDP A H1453 D1455 N1489 A1490 T1491 H99 D101 N135 A136 T137
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:2zej, PDBe:2zej, PDBj:2zej
PDBsum2zej
PubMed18230735
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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