Structure of PDB 2zdu Chain A

Receptor sequence
>2zduA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR
HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLT
FPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY
INVWYDPAEVEAREHTIEEWKELIYKEVMN
3D structure
PDB2zdu Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162 T168
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 446 A K68 I70 G71 A91 M146 E147 M149 D150 A151 N152 S193 V196 L206 K23 I25 G26 A46 M101 E102 M104 D105 A106 N107 S148 V151 L161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2zdu, PDBe:2zdu, PDBj:2zdu
PDBsum2zdu
PubMed18313304
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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