Structure of PDB 2zbw Chain A

Receptor sequence
>2zbwA (length=333) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
ADHTDVLIVGAGPTGLFAGFYVGMRGLSFRFVDPLPEPGGQLTALYPEKY
IYDVAGFPKVYAKDLVKGLVEQVAPFNPVYSLGERAETLEREGDLFKVTT
SQGNAYTAKAVIIAAGVGAFEPRRIGAPGEREFEGRGVYYAVKSKAEFQG
KRVLIVGGGDSAVDWALNLLDTARRITLIHRRPQFRAHEASVKELMKAHE
EGRLEVLTPYELRRVEGDERVRWAVVFHNQTQEELALEVDAVLILAGYIT
KLGPLANWGLALEKNKIKVDTTMATSIPGVYACGDIVTYPGKLPLIVLGF
GEAAIAANHAAAYANPALKVNPGHSSEKAAPGT
3D structure
PDB2zbw Crystal structure of thioredoxin reductase-like protein from Thermus thermophilus HB8
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P40 L44 L47 K145 S146
Catalytic site (residue number reindexed from 1) P38 L42 L45 K143 S144
Enzyme Commision number 1.18.1.2: ferredoxin--NADP(+) reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V11 G12 G14 P15 T16 V34 D35 P36 G42 Q43 L44 Y48 D55 R87 A88 A116 A117 G118 G120 A121 F122 G286 D287 I298 V9 G10 G12 P13 T14 V32 D33 P34 G40 Q41 L42 Y46 D53 R85 A86 A114 A115 G116 G118 A119 F120 G284 D285 I296
BS02 FAD A H326 S327 S328 H324 S325 S326
Gene Ontology
Molecular Function
GO:0004324 ferredoxin-NADP+ reductase activity
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification

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Molecular Function
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Biological Process
External links
PDB RCSB:2zbw, PDBe:2zbw, PDBj:2zbw
PDBsum2zbw
PubMed
UniProtQ5SL28|FENR_THET8 Ferredoxin--NADP reductase (Gene Name=TTHA0465)

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