Structure of PDB 2zas Chain A

Receptor sequence
>2zasA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
KPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG
WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYI
MDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMH
IEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKA
VQHFYNIKLEGKVPMHKLFLEMLEAKV
3D structure
PDB2zas ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1OH A L268 E275 M306 L309 Y326 L345 I349 F435 L37 E44 M75 L78 Y95 L114 I118 F204 MOAD: ic50=13.9nM
PDBbind-CN: -logKd/Ki=7.86,IC50=13.9nM
BindingDB: IC50=13.9nM
External links
PDB RCSB:2zas, PDBe:2zas, PDBj:2zas
PDBsum2zas
PubMed18582436
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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