Structure of PDB 2zao Chain A

Receptor sequence

>2zaoA (length=312) Species: 10090 (Mus musculus) [Search protein sequence]

IVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLF
GPPGTGKSYLAKAVATEANNSTFFSISSSSEKLVKNLFQLARENKPSIIF
IDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPW
VLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQELGRK
TDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLT
PCSPGDPGAIEMTWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLK
LKKFTEDFGQEG

3D structure

PDB

2zao Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.6: vesicle-fusing ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	A137 P176 G177 T178 G179 K180 S181 Y182 M309 H313 G338 S342	A14 P53 G54 T55 G56 K57 S58 Y59 M177 H181 G206 S210

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044877	protein-containing complex binding

	Biological Process
GO:0001525	angiogenesis
GO:0001778	plasma membrane repair
GO:0006813	potassium ion transport
GO:0006914	autophagy
GO:0006997	nucleus organization
GO:0007032	endosome organization
GO:0007034	vacuolar transport
GO:0007080	mitotic metaphase chromosome alignment
GO:0007417	central nervous system development
GO:0010824	regulation of centrosome duplication
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0030301	cholesterol transport
GO:0031468	nuclear membrane reassembly
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
GO:0033993	response to lipid
GO:0036258	multivesicular body assembly
GO:0039702	viral budding via host ESCRT complex
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046761	viral budding from plasma membrane
GO:0051261	protein depolymerization
GO:0051301	cell division
GO:0060070	canonical Wnt signaling pathway
GO:0060856	establishment of blood-brain barrier
GO:0061738	late endosomal microautophagy
GO:0061764	late endosome to lysosome transport via multivesicular body sorting pathway
GO:0061952	midbody abscission
GO:0071985	multivesicular body sorting pathway
GO:0090148	membrane fission
GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO:0097352	autophagosome maturation
GO:1901673	regulation of mitotic spindle assembly
GO:1903542	negative regulation of exosomal secretion
GO:1903543	positive regulation of exosomal secretion
GO:1903724	positive regulation of centriole elongation
GO:1904903	ESCRT III complex disassembly

	Cellular Component
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0090543	Flemming body
GO:1904949	ATPase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2zao, PDBe:2zao, PDBj:2zao
PDBsum	2zao
PubMed	18796009
UniProt	P46467\|VPS4B_MOUSE Vacuolar protein sorting-associated protein 4B (Gene Name=Vps4b)

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