Structure of PDB 2z8c Chain A

Receptor sequence
>2z8cA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
FVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN
ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGD
LKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDL
AARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD
GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
3D structure
PDB2z8c Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.
ChainA
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1132 A1134 R1136 N1137 D1150 E1159 L1171 P1172
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D167 E176 L188 P189
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D1132 R1136 G1169 L1170 L1171 L1219 D149 R153 G186 L187 L188 L236
BS02 S91 A L1002 A1028 L1078 M1079 G1082 D1083 R1136 M1139 L19 A45 L95 M96 G99 D100 R153 M156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z8c, PDBe:2z8c, PDBj:2z8c
PDBsum2z8c
PubMed18767165
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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