Structure of PDB 2z86 Chain A

Receptor sequence
>2z86A (length=580) Species: 562 (Escherichia coli) [Search protein sequence]
IDIDAATKIMCSNAKAISLNEVEKNEIISKYREITAKKSERAELKEVEPI
PLDWPSDLTLPPLPESTNDYVWAGKRKELLIIDGLSIVIPTYNRAKILAI
TLACLCNQKTIYDYEVIVADDGSKENIEEIVREFESLLNIKYVRQKDYGY
QLCAVRNLGLRAAKYNYVAILDCDMAPNPLWVQSYMELLAVDDNVALIGP
RKYIDTSKHTYLDFLSQKSLINEIPESVDWRIEHFKNTDNLRLCNTPFRF
FSGGNVAFAKKWLFRAGWFDEEFTHWGGEDNEFGYRLYREGCYFRSVEGA
MAYHQEPPQLLQQKVPYFYRKKEKIESATLKRVPLVSIYIPAYNCSKYIV
RCVESALNQTITDLEVCICDDGSTDDTLRILQEHYANHPRVRFISQKNKG
IGSASNTAVRLCRGFYIGQLDSDDFLEPDAVELCLDEFRKDLSLACVYTT
NRNIDREGNLISNGYNWPIYSREKLTSAMICHHFRMFTARAWNLTEGFNE
SISNAVDYDMYLKLSEVGPFKHINKICYNRVLHSIKKLDIQKENHFKVVN
ESLSRLGIKKYKYSPLTNLNECRKYTWEKI
3D structure
PDB2z86 Crystal structure of chondroitin polymerase from Escherichia coli K4.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UGA A P157 T158 Y159 D188 Y217 R223 D239 D362 H386 P90 T91 Y92 D121 Y150 R156 D172 D280 H304
BS02 UGA A P439 Y441 D469 N496 I499 Q517 D519 S520 H581 N602 A603 V604 D605 P341 Y343 D371 N398 I401 Q419 D421 S422 H483 N504 A505 V506 D507
BS03 MN A R161 D241 H386 R94 D174 H304
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2z86, PDBe:2z86, PDBj:2z86
PDBsum2z86
PubMed18771653
UniProtQ8L0V4|CHS_ECOLX Chondroitin synthase (Gene Name=kfoC)

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