Structure of PDB 2z7x Chain A

Receptor sequence
>2z7xA (length=549) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCV
NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSL
TFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFL
EELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI
SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY
DLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEY
LKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH
SMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNL
PQLKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQ
KIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGKPVRSIICP
3D structure
PDB2z7x Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N294 Y326 D327 N268 Y300 D301
BS02 PCJ A L282 L312 F325 Y326 D327 L334 V348 F349 L350 P352 Y376 L256 L286 F299 Y300 D301 L308 V322 F323 L324 P326 Y350
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z7x, PDBe:2z7x, PDBj:2z7x
PDBsum2z7x
PubMed17889651
UniProtO60603|TLR2_HUMAN Toll-like receptor 2 (Gene Name=TLR2)

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