Structure of PDB 2z7r Chain A

Receptor sequence
>2z7rA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
GSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK
VILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED
VKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEGT
VEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL
KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTID
WNKLYRREIKPPFKP
3D structure
PDB2z7r Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D187 K189 E191 N192 D205 T225
Catalytic site (residue number reindexed from 1) D124 K126 E128 N129 D142 T150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L68 G69 A92 K94 D142 F143 L144 D148 E191 N192 L194 T204 L16 G17 A40 K42 D79 F80 L81 D85 E128 N129 L131 T141 MOAD: ic50~0.4nM
PDBbind-CN: -logKd/Ki=9.52,IC50=0.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2z7r, PDBe:2z7r, PDBj:2z7r
PDBsum2z7r
PubMed17965187
UniProtQ15418|KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (Gene Name=RPS6KA1)

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