Structure of PDB 2z6j Chain A

Receptor sequence
>2z6jA (length=307) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEV
VKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPS
KYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTT
MTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKES
NAHPNYKEKILKARDIDTTISAQHAVRAIKNQLTRDFELAEKDAFEQMGA
GALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEE
ASRWTGV
3D structure
PDB2z6j Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.12.16: nitronate monooxygenase.
1.3.-.-
1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A A158 I161 A158 I161
BS02 FMN A G18 G19 M20 A21 N69 E137 A141 G142 G169 G170 G191 T192 G18 G19 M20 A21 N69 E137 A141 G142 G169 G170 G191 T192
BS03 TUI A N45 M71 L73 A96 G97 V116 P118 L122 E137 H144 N45 M71 L73 A96 G97 V116 P118 L122 E137 H144 MOAD: Ki<29nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0018580 nitronate monooxygenase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2z6j, PDBe:2z6j, PDBj:2z6j
PDBsum2z6j
PubMed18305197
UniProtQ9FBC5

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