Structure of PDB 2z5x Chain A

Receptor sequence
>2z5xA (length=513) Species: 9606 (Homo sapiens) [Search protein sequence]
HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVD
YVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGA
FPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELI
DKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVT
NGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNH
EHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYK
EAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRL
AKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYF
PPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLN
GLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSV
TALGFVLYKYKLL
3D structure
PDB2z5x Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G71 R206 K305
Catalytic site (residue number reindexed from 1) G60 R195 K294
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
1.4.3.4: monoamine oxidase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008131 primary methylamine oxidase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052595 aliphatic amine oxidase activity
GO:0097621 monoamine oxidase activity
Biological Process
GO:0006576 biogenic amine metabolic process
GO:0006584 catecholamine metabolic process
GO:0009967 positive regulation of signal transduction
GO:0042420 dopamine catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:2z5x, PDBe:2z5x, PDBj:2z5x
PDBsum2z5x
PubMed18391214
UniProtP21397|AOFA_HUMAN Amine oxidase [flavin-containing] A (Gene Name=MAOA)

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