Structure of PDB 2z4y Chain A

Receptor sequence
>2z4yA (length=291) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGRLNLIVQINRVMN
LPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTIN
TANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDF
LPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSLVPFINLLGIIYQI
RDDYLNLKDFQKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRIL
LLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKND
3D structure
PDB2z4y Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 252 A D80 R89 L143 K174 Q211 D214 K238 D74 R83 L137 K168 Q199 D202 K222 MOAD: ic50=0.71uM
PDBbind-CN: -logKd/Ki=6.15,IC50=0.71uM
BS02 252 A G40 R44 H73 R89 R90 G37 R38 H67 R83 R84 MOAD: ic50=0.71uM
PDBbind-CN: -logKd/Ki=6.15,IC50=0.71uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015031 protein transport
GO:0016114 terpenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z4y, PDBe:2z4y, PDBj:2z4y
PDBsum2z4y
PubMed18800762
UniProtQ12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)

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