Structure of PDB 2z4t Chain A

Receptor sequence

>2z4tA (length=493) Species: 426532 (Photobacterium sp. JT-ISH-224) [Search protein sequence]

TQSIIKNDINKTIIDEEYVNLEPINQSNISFTKHSWVQTCGTQQLLTEQN
KESISLSVVAPRLDDDEKYCFDFNGVSNKGEKYITKVTLNVVAPSLEVYV
DHASLPTLQQLMDIIKSEEENPTAQRYIAWGRIVPTDEQMKELNITSFAL
INNHTPADLVQEIVKQAQTKHRLNVKLSSNTAHSFDNLVPILKELNSFNN
VTVTNIDLYDDGSAEYVNLYNWRDTLNKTDNLKIGKDYLEDVINGINEDT
SNTGTSSVYNWQKLYPANYHFLRKDYLTLEPSLHELRDYIGDSLKQMQWD
GFKKFNSKQQELFLSIVNFDKQKLQNEYNSSNLPNFVFTGTTVWAGNHER
EYYAKQQINVINNAINESSPHYLGNSYDLFFKGHPGGGIINTLIMQNYPS
MVDIPSKISFEVLMMTDMLPDAVAGIASSLYFTIPAEKIKFIVFTSTETI
TDRETALRSPLVQVMIKLGIVKEENVLFWADLPNCETGVCIAV

3D structure

PDB

2z4t Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	N174 W365	N153 W344
BS02	GAL	A	H123 H204 D232 W365	H102 H183 D211 W344
BS03	C5P	A	G361 K403 G404 H405 P406 S430 F431 E432 S449 S450 L451	G340 K382 G383 H384 P385 S409 F410 E411 S428 S429 L430
BS04	PO4	A	K295 K316 Q317	K274 K295 Q296
BS05	PO4	A	V492 K493 N496	V471 K472 N475
BS06	MG	A	Y349 S352 L354 N356	Y328 S331 L333 N335
BS07	MG	A	D122 H123 A124 T128 G152 R153	D101 H102 A103 T107 G131 R132
BS08	MG	A	E301 P302 S303	E280 P281 S282

Gene Ontology

	Molecular Function
GO:0016757	glycosyltransferase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:2z4t, PDBe:2z4t, PDBj:2z4t
PDBsum	2z4t
PubMed	17962295
UniProt	A8QYL1

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