Structure of PDB 2z4b Chain A

Receptor sequence
>2z4bA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
DALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKKI
PGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDE
GKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVSS
RKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGM
EHLLNMKVPVYDLLLEMLNAH
3D structure
PDB2z4b Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DC8 A M295 E305 M336 L339 I376 F377 H475 L476 M29 E39 M70 L73 I110 F111 H202 L203 MOAD: Ki=0.44nM
PDBbind-CN: -logKd/Ki=9.36,Ki=0.44nM
BindingDB: Ki=0.44nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2z4b, PDBe:2z4b, PDBj:2z4b
PDBsum2z4b
PubMed17614275
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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