Structure of PDB 2z2p Chain A

Receptor sequence
>2z2pA (length=293) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
EFKLQELNLTNQDTGPYGITVSDKGKVWITQHKANMISCINLDGKITEYE
LPNKGAKVMCLTISSDGEVWFTENAANKIGRITKKGIIKEYTLPNPDSAP
YGITEGPNGDIWFTEMNGNRIGRITDDGKIREYELPNKGSYPSFITLGSD
NALWFTENQNNAIGRITESGDITEFKIPTPASGPVGITKGNDDALWFVEI
IGNKIGRITTSGEITEFKIPTPNARPHAITAGAGIDLWFTEWGANKIGRL
TSNNIIEEYPIQIKSAEPAGICFDGETIWFAMECDKIGKLTLI
3D structure
PDB2z2p Structural Basis for Streptogramin B Resistance in Staphylococcus Aureus by Virginiamycin B Lyase
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y18 H33 Y102 M117 S144 Q160 A182 G184 V186 H228 W243 E268 E284 Y17 H32 Y101 M116 S143 Q159 A181 G183 V185 H227 W242 E267 E283
BS02 peptide A D24 S66 N152 D23 S65 N151
BS03 MG A E268 E284 E267 E283
BS04 MG A D67 E69 D127 D66 E68 D126
BS05 DOL A K34 W243 E268 K33 W242 E267
BS06 DOL A N152 E169 N151 E168
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Cellular Component
External links
PDB RCSB:2z2p, PDBe:2z2p, PDBj:2z2p
PDBsum2z2p
PubMed17563376
UniProtP17978|VGB_STAAU Virginiamycin B lyase (Gene Name=vgb)

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