Structure of PDB 2yyj Chain A

Receptor sequence
>2yyjA (length=476) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHD
PRYREVLTYEEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRS
PDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNR
ARPPSGQPDPYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSTLLQ
AGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLSSRVEEMDCLVI
FDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFLG
VAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLL
VPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFL
EKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQT
LYNVYNKEPYKERIRAFLKESLKVFE
3D structure
PDB2yyj Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8
ChainA
Resolution1.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M97 S101 T185 D247 A285 V289 L291 Y437
Catalytic site (residue number reindexed from 1) M96 S100 T184 D246 A284 V288 L290 Y436
Enzyme Commision number 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0050660 flavin adenine dinucleotide binding
GO:0052881 4-hydroxyphenylacetate 3-monooxygenase activity
Biological Process
GO:0009056 catabolic process
GO:0010124 phenylacetate catabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:2yyj, PDBe:2yyj, PDBj:2yyj
PDBsum2yyj
PubMed17804419
UniProtQ5SJP8|HPAB_THET8 4-hydroxyphenylacetate 3-monooxygenase oxygenase component (Gene Name=TTHA0960)

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